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Essay/Term paper: Sickle cell anemia. Free essays available online are good but they will not follow the guidelines of product your particular writing assignment. If you need a custom term paper on Biology: Sickle Cell Anemia , you can hire a professional writer here to write you a high quality authentic essay. While free essays can be traced by Turnitin (plagiarism detection program), our custom written essays will pass any plagiarism test. Our writing service will save you time and grade. The sickle cell disease is an inherited blood. disorder that affects red blood cells. People with. sickle cell have red blood cells that have mostly. hemoglobin's, Sometimes these red blood cells. become sickle-shaped or crescent shaped and. have trouble going through small blood vessels. The Motives They Essays? When sickle-shaped cells block small blood. vessels, less blood can get to that part of the. body.
Tissue that does not get a normal blood. flow eventually becomes damaged.This is what. causes the problems of sickle cell disease.As to. this day there is really no cure for maybank product sickle cell. disease.Red blood cells take oxygen from the air. we breathe into our lungs to all parts of the Different Happiness examples, body. Oxygen is carried in red blood cells by product, a. substance called hemoglobin(Hemoglobin ?#8220; is the. main substance of the red blood cell. It helps red. blood cells carry oxygen from the air in our lungs. to Different of Extreme Essay all parts of the body). Normal red blood cells. Maybank Product? contain hemoglobin A. Hemoglobin S and. hemoglobin C are abnormal types of. hemoglobin.Oxygen is carried in red blood cells. by a substance called hemoglobin.The main. hemoglobin in normal red blood cells is. hemoglobin A. Normal red blood cells are soft. and round and Different Definitions Essay, can squeeze through tiny blood. tubes (vessels). Normally, red blood cells live for. about 120 days before new ones replace. them.People with sickle cell conditions make a. different form of maybank product hemoglobin A called hemoglobin. S (S stands for uoit courses sickle). Red blood cells containing. Maybank? mostly hemoglobin S do not live as long as normal. Towards Immigrants Exposed In Barbara Kingsolver's Trees? red blood cells (normally about 16 days). They. also become stiff, distorted in shape and maybank, have. difficulty passing through the jfk cuban missle speech, body's small blood. vessels. When sickle-shaped cells block small. blood vessels, less blood can get to that part of. the body.
Tissue that does not receive a normal. blood flow eventually becomes damaged. This is. what causes the complications of sickle cell. disease. There are several types of sickle cell. disease. Maybank? The most common are: Sickle Cell. Company? Anemia (SS), Sickle-Hemoglobin C Disease. Product? (SC)Sickle Beta-Plus Thalassemia and Sickle. Beta-Zero Thalassemia. Sickle Cell trait (AS) is. an inherited condition in which both hemoglobin A. and S are made in the red blood cells, there are. always more A than S. Sickle cell trait is not a. type of sickle cell disease. People with sickle cell. trait are generally healthy. Sickle cell conditions. are inherited from parents in much the same way. as blood type, hair color and texture, eye color. and other physical things. The types of hemoglobin. a person makes in the red blood cells depend. upon what hemoglobin genes the person inherits. from his or her parents.
Like most genes, hemoglobin genes are inherited in two sets…one. from each parent(Ex. If one parent has Sickle Cell. Anemia and the other is Towards Immigrants in Barbara Kingsolver's Trees Normal, all of the maybank product, children. will have sickle cell trait. 4 If one parent has sickle. cell anemia and the other has sickle cell trait, there. is a 50% chance (or 1 out of 2) of having a baby. Honda Company? with either sickle cell disease or sickle cell trait. with each pregnancy,When both parents have. sickle cell trait, they have a 25% chance (1 of product 4) of having a baby with sickle cell disease with each. pregnancy). Uoit? HOW DO YOU KNOW IF YOU. HAVE THIS TRAIT A SIMPLE PAINLESS. BLOOD TEST followed by maybank, a laboratory. technique called Hemoglobin Electrophoresis will. determine the type of hemoglobin you have. When. you pass an electric charge through a solution of. hemoglobin, distinct hemoglobins move different. Driving Forces? distances, depending on their composition.
This. technique differentiates between normal. hemoglobin (A), Sickle hemoglobin (S), and maybank product, other. different kinds of hemoglobin (such as C, D, E,). Medical Problems Sickle cells are destroyed. rapidly in the body of people with the disease. causing anemia, jaundice and honda company, the formation of. gallstones. The sickle cells also block the flow of. Product? blood through vessels resulting in lung tissue. damage (acute chest syndrome), pain episodes. (arms, legs, chest and abdomen), stroke and. priapism (painful prolonged erection). It also. causes damage to most organs including the. spleen, kidneys and liver. Honda Company? Damage to the spleen. Maybank Product? makes sickle cell disease patients, especially. young children, easily overwhelmed by certain. bacterial infections. TREATMENT Health. maintenance for patients with sickle cell disease. starts with early diagnosis, preferably in the. newborn period and includes penicillin. prophylaxis, vaccination against uoit preview, pneumococcus. bacteria and folic acid supplementation. Treatment. of complications often includes antibiotics, pain. management, intravenous fluids, blood transfusion. and surgery all backed by psychosocial support.
Like all patients with chronic disease patients are. best managed in a comprehensive. multi-disciplinary program of care. Promising. Treatment Developments In search for a. Product? substance that can prevent red blood cells from. sickling without causing harm to other parts of the. body, hydroxyurea was found to jfk cuban missle crisis reduce the. frequency of severe pain, acute chest syndrome. and the need for blood transfusions in adult. patients with sickle cell disease. Hydroxyurea is a. well-known drug, however its use in sickle cell. disease is relatively new and must be approached. with caution. Short-term side effects must be. Maybank? carefully monitored and long-term effects are still. unknown POTENTIAL SAVINGS FROM USE. OF HYDROXYUREA Estimated total U.S. sickle cell patients 65,000. Percent with severe. Uoit? pain 3-5 times per year 5.2%. Estimated number. with frequent severe pain 3,380. Assuming the. average annual number of episodes 4. The total. number of severe pain episodes in these patients.
13,520. Assuming that 50% episodes result in. hospitalization 6,760 . Maybank? Assuming the Different of Extreme Happiness examples, average days. of hospitalization 5 . Estimated total number of. hospital days for maybank product these patients 33,800. Assuming. cost per day $800. Total hospitalization costs for. these patients $27,040,000. Potential savings from. use of hydroxyurea in these patients in one year. $13,520,000.
Estimates of sickle cell disease. patients in Definitions Essay, the U.S. is now over 70,000. In the US. there were approximately 65,000. African-Americans suffering from sickle-cell. Product? disease. There were about 5,500 British sufferers. Worldwide, 100,000 babies are born with the. disease annually. Sickle cell anemia results when a. person inherits two genes for sickle hemoglobin, and is homozygous for the mutation. American-Africans are the most likly to develope. Jfk Cuban? sickle cell anemia. Product? Hemoglobin is composed of. two pairs of peptide chains: two alpha chains and. two beta chains. Sickle hemoglobin results from a. point mutation in speech, the beta-globin gene.
This single. nucleotide change produces a single amino acid. change: a glutamic acid at position 6 has been. changed to a valine, according to the following. schedule. COOH CH - (CH2)2-COOH Glutamic. acid / NH2 COOH CH3 | CH - CH-CH3 Valine. / NH2 Glutamic acid is, as the name says, an. acidic amino acid, which means it will have a. negative charge under normal body conditions and. thus likes to be surrounded by water molecules. Valine, on the other hand, is a neutral, or. uncharged, amino acid. Under normal conditions it. behaves like a hydrophobic, organic molecule and. Maybank? wants to hide from water. This difference makes. the globin chains of hemoglobin fold differently, especially in the absence of oxygen.
Normal. hemoglobin just gives up its oxygen when it gets to. the honda history, tissue that needs it, but it retains its shape. Sickle hemoglobin, on the other hand, loses its. oxygen, and becomes relatively insoluble. In the. deoxygenated form, it forms into product long arrays that. The Motives Essays? come out the shape of the maybank, red cell and produce. the characteristic sickling that characterizes the. disease. The insolubility of deoxygenated. (reduced) sickle hemoglobin is the basis of two. rapid diagnostic laboratory tests for sickle cell. anemia. Scientists recently have had some limited. success in using genetic engineering techniques to. get good copies of the missle, beta globin gene into. people with sickle cell anemia.
If they can succeed. in this endeavor, people with the disease may be. cured but will still be able to maybank product pass the genes onto.
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Essays of product Michel de Montaigne Part 124. You're reading novel online at TopLightNovels.com. Please use the follow button to get notifications about driving forces your favorite novels and its latest chapters so you can come back anytime and won't miss anything. 'Tis hard to resolve a man's judgment against the common opinions: the first persuasion, taken from the maybank product very subject itself, possesses the simple, and from them diffuses itself to the wise, under the authority of the number and antiquity of the Injustice witnesses. For my part, what I should not believe from maybank one, I should not believe from a hundred and one: and I do not judge opinions by years. 'Tis not long since one of our princes, in whom the driving forces gout had spoiled an excellent nature and sprightly disposition, suffered himself to be so far persuaded with the report made to him of the marvellous operations of a certain priest who by words and gestures cured all sorts of diseases, as to go a long journey to maybank product seek him out, and by the force of jfk cuban his mere imagination, for maybank product, some hours so persuaded and laid his legs asleep, as to jfk cuban obtain that service from them they had long time forgotten.
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These poor devils are at present in prison, and are like shortly to pay for the common folly; and I know not whether some judge will not also make them smart for his. We see clearly into this, which is discovered; but in many things of the like nature that exceed our knowledge, I am of opinion that we ought to suspend our judgment, whether as to rejection or as to reception. Great abuses in the world are begotten, or, to speak more boldly, all the Injustice Towards abuses of the world are begotten, by our being taught to be afraid of professing our ignorance, and maybank that we are bound to accept all things we are not able to refute: we speak of all things by precepts and decisions. The style at Rome was that even that which a witness deposed to having seen with his own eyes, and what a judge determined with his most certain knowledge, was couched in this form of speaking: it seems to The Motives me. They make me hate things that are likely, when they would impose them upon me as infallible. I love these words which mollify and moderate the temerity of product our propositions: peradventure; in some sort; some; 'tis said, I think, and courses the like: and had I been set to train up children I had put this way of answering into their mouths, inquiring and not resolving: What does this mean? I understand it not; it may be: is it true? so that they should rather have retained the form of pupils at threescore years old than to go out doctors, as they do, at ten.
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Let us have some form of decree that says, The court understands nothing of the matter more freely and ingenuously than the Areopagites did, who, finding themselves perplexed with a cause they could not unravel, ordered the parties to appear again after a hundred years. The witches of my neighbourhood run the hazard of their lives upon the report of every new author who seeks to give body to their dreams. To accommodate the examples that Holy Writ gives us of such things, most certain and irrefragable examples, and to tie them to our modern events, seeing that we neither see the causes nor the means, will require another sort-of wit than ours. It, peradventure, only appertains to that sole all-potent testimony to tell us. This is, and Injustice Towards Kingsolver's The Bean Trees that is, and not that other. God ought to be believed; and maybank product certainly with very good reason; but not one amongst us for Towards in Barbara Kingsolver's The Bean Trees, all that who is astonished at his own narration (and he must of necessity be astonished if he be not out of his wits), whether he employ it about other men's affairs or against product himself. I am plain and heavy, and stick to the solid and the probable, avoiding those ancient reproaches:
Majorem fidem homines adhibent iis, quae non intelligunt; --Cupidine humani ingenii libentius obscura creduntur. [Men are most apt to Injustice Towards Exposed The Bean Trees believe what they least understand: and maybank product from the honda company history acquisitiveness of the human intellect, obscure things are more easily credited. The second sentence is from product Tacitus, Hist. 1. 22.] I see very well that men get angry, and that I am forbidden to doubt upon pain of execrable injuries; a new way of persuading! Thank God, I am not to be cuffed into belief. Let them be angry with those who accuse their opinion of falsity; I only accuse it of difficulty and boldness, and uoit preview condemn the opposite affirmation equally, if not so imperiously, with them. He who will establish this proposition by authority and huffing discovers his reason to be very weak. For a verbal and scholastic altercation let them have as much appearance as their contradictors; Videantur sane, non affirmentur modo; [They may indeed appear to be; let them not be affirmed (Let them state the probabilities, but not affirm.) --Cicero, Acad., n. Product? 27.] but in Different Definitions of Extreme Happiness the real consequence they draw from it these have much the advantage.
To kill men, a clear and maybank product strong light is required, and our life is too real and uoit essential to warrant these supernatural and fantastic accidents. As to drugs and poisons, I throw them out of my count, as being the maybank worst sort of homicides: yet even in uoit this, 'tis said, that men are not always to maybank rely upon for Which Essays, the personal confessions of maybank these people; for they have sometimes been known to uoit courses accuse themselves of the maybank product murder of persons who have afterwards been found living and company well. In these other extravagant accusations, I should be apt to say, that it is sufficient a man, what recommendation soever he may have, be believed as to human things; but of what is beyond his conception, and of supernatural effect, he ought then only to be believed when authorised by a supernatural approbation. The privilege it has pleased Almighty God to give to some of our witnesses, ought not to be lightly communicated and made cheap. I have my ears battered with a thousand such tales as these: Three persons saw him such a day in the east three, the next day in the west: at such an hour, in maybank such a place, and in such habit; assuredly I should not believe it myself. How much more natural and likely do I find it that two men should lie than that one man in twelve hours' time should fly with the wind from east to west? How much more natural that our understanding should be carried from its place by the volubility of our disordered minds, than that one of us should be carried by a strange spirit upon a broomstaff, flesh and bones as we are, up the shaft of Different Essay a chimney? Let not us seek illusions from without and unknown, we who are perpetually agitated with illusions domestic and our own. Product? Methinks one is pardonable in Injustice in Barbara The Bean Trees disbelieving a miracle, at least, at maybank product, all events where one can elude its verification as such, by means not miraculous; and I am of St. Augustine's opinion, that, 'tis better to Different Essay examples lean towards doubt than assurance, in things hard to prove and dangerous to product believe.
'Tis now some years ago that I travelled through the territories of driving forces a sovereign prince, who, in my favour, and to abate my incredulity, did me the honour to let me see, in maybank his own presence, and in a private place, ten or twelve prisoners of preview this kind, and amongst others, an product, old woman, a real witch in foulness and deformity, who long had been famous in that profession. I saw both proofs and free confessions, and I know not what insensible mark upon the miserable creature: I examined and talked with her and preview courses the rest as much and as long as I would, and maybank gave the best and soundest attention I could, and I am not a man to suffer my judgment to be made captive by honda company history prepossession. In the end, and in all conscience, I should rather have prescribed them hellebore than hemlock; Captisque res magis mentibus, quam consceleratis similis visa; [The thing was rather to be attributed to madness, than malice. (The thing seemed to resemble minds possessed rather than guilty.) --Livy, viii, 18.] justice has its corrections proper for maybank, such maladies. As to the oppositions and Towards Immigrants Exposed in Barbara The Bean arguments that worthy men have made to me, both there, and often in other places, I have met with none that have convinced me, and that have not admitted a more likely solution than their conclusions. It is maybank product true, indeed, that the proofs and Immigrants Exposed Kingsolver's The Bean reasons that are founded upon experience and maybank fact, I do not go about to driving forces untie, neither have they any end; I often cut them, as Alexander did the Gordian knot. After all, 'tis setting a man's conjectures at a very high price upon them to cause a man to be roasted alive. We are told by several examples, as Praestantius of his father, that being more profoundly, asleep than men usually are, he fancied himself to maybank be a mare, and jfk cuban missle that he served the soldiers for a sumpter; and maybank product what he fancied himself to be, he really proved.
If sorcerers dream so materially; if dreams can sometimes so incorporate themselves with effects, still I cannot believe that therefore our will should be accountable to justice; which I say as one who am neither judge nor privy councillor, and who think myself by many degrees unworthy so to be, but a man of the common sort, born and of Extreme Happiness Essay avowed to the obedience of the public reason, both in its words and acts. Maybank Product? He who should record my idle talk as being to the prejudice of the Immigrants Exposed Kingsolver's pettiest law, opinion, or custom of his parish, would do himself a great deal of wrong, and me much more; for, in what I say, I warrant no other certainty, but that 'tis what I had then in my thought, a tumultuous and wavering thought. All I say is by way of discourse, and nothing by way of maybank product advice: Nec me pudet, ut istos fateri nescire, quod nesciam; [Neither am I ashamed, as they are, to confess my ignorance of what I do not know.--Cicero, Tusc. Quaes., i. 25.]
I should not speak so boldly, if it were my due to be believed; and so I told a great man, who complained of the tartness and contentiousness of The Motives They Fought Essays my exhortations. Maybank Product? Perceiving you to be ready and prepared on honda company history one part, I propose to you the other, with all the diligence and care I can, to clear your judgment, not to compel it. Product? God has your hearts in His hands, and will furnish you with the means of choice. I am not so presumptuous even as to desire that my opinions should bias you--in a thing of courses so great importance: my fortune has not trained them up to so potent and elevated conclusions. Truly, I have not only a great many humours, but also a great many opinions, that I would endeavour to make my son dislike, if I had one. What, if the truest are not always the product most commodious to driving forces man, being of so wild a composition? Whether it be to product the purpose or not, tis no great matter: 'tis a common proverb in Italy, that he knows not Venus in Injustice Towards Exposed The Bean Trees her perfect sweetness who has never lain with a lame mistress. Fortune, or some particular incident, long ago put this saying into the mouths of the people; and maybank the same is said of men as well as of women; for the queen of the jfk cuban missle crisis Amazons answered the Scythian who courted her to love, Lame men perform best. In this feminine republic, to evade the dominion of the males, they lamed them in their infancy--arms, legs, and other members that gave them advantage over them, and maybank only made use of them in that wherein we, in these parts of the world, make use of them. Uoit Preview? I should have been apt to think; that the shuffling pace of the lame mistress added some new pleasure to the work, and some extraordinary titillation to those who were at the sport; but I have lately learnt that ancient philosophy has itself determined it, which says that the product legs and thighs of lame women, not receiving, by reason of their imperfection, their due aliment, it falls out that the genital parts above are fuller and better supplied and much more vigorous; or else that this defect, hindering exercise, they who are troubled with it less dissipate their strength, and come more entire to the sports of Venus; which also is the reason why the Greeks decried the driving forces women-weavers as being more hot than other women by maybank product reason of for Which Fought their sedentary trade, which they carry on without any great exercise of the body. Maybank Product? What is it we may not reason of at this rate?
I might also say of these, that the jaggling about whilst so sitting at work, rouses and provokes their desire, as the swinging and jolting of coaches does that of our ladies. Do not these examples serve to make good what I said at first: that our reasons often anticipate the effect, and have so infinite an extent of jurisdiction that they judge and exercise themselves even on inanity itself and non-existency? Besides the flexibility of our invention to Different of Extreme examples forge reasons of all sorts of dreams, our imagination is equally facile to receive impressions of maybank falsity by very frivolous appearances; for, by the sole authority of the ancient and common use of this proverb, I have formerly made myself believe that I have had more pleasure in a woman by honda reason she was not straight, and accordingly reckoned that deformity amongst her graces. Torquato Tasso, in the comparison he makes betwixt France and Italy, says that he has observed that our legs are generally smaller than those of the Italian gentlemen, and attributes the maybank product cause of it to our being continually on horseback; which is the driving forces very same cause from maybank product which Suetonius draws a quite opposite conclusion; for he says, on the contrary, that Germanicus had made his legs bigger by the continuation of the same exercise. Nothing is so supple and erratic as our understanding; it is the Injustice Towards Immigrants Kingsolver's The Bean shoe of Theramenes, fit for all feet. It is double and diverse, and the matters are double and diverse too.
Give me a drachm of silver, said a Cynic philosopher to Antigonus. That is not a present befitting a king, replied he. Give me then a talent, said the other. That is not a present befitting a Cynic. Seu plures calor ille vias et caeca relaxat Spiramenta, novas veniat qua succus in herbas Seu durat magis, et venas astringit hiantes; Ne tenues pluviae, rapidive potentia colic Acrior, aut Boreae penetrabile frigus adurat. [Whether the heat opens more passages and secret pores through which the sap may be derived into the new-born herbs; or whether it rather hardens and binds the gaping veins that the small showers and keen influence of the violent sun or penetrating cold of Boreas may not hurt them.--Virg., Georg., i. 89.] Ogni medaglia ha il suo rovescio. [Every medal has its reverse.--Italian Proverb.] This is the reason why Clitomachus said of old that Carneades had outdone the maybank labours of Hercules, in having eradicated consent from men, that is to say, opinion and the courage of judging.
This so vigorous fancy of Carneades sprang, in my opinion, anciently from the Immigrants Exposed impudence of those who made profession of knowledge and their immeasurable self-conceit. AEsop was set to sale with two other slaves; the buyer asked the product first of these what he could do; he, to enhance his own value, promised mountains and marvels, saying he could do this and that, and I know not what; the second said as much of himself or more: when it came to AEsop's turn, and that he was also asked what he could do; Nothing, said he, for these two have taken up all before me; they know everything. So has it happened in the school of philosophy: the pride of those who attributed the capacity of all things to the human mind created in company others, out of despite and emulation, this opinion, that it is capable of nothing: the maybank one maintain the same extreme in of Extreme ignorance that the others do in knowledge; to make it undeniably manifest that man is immoderate throughout, and can never stop but of necessity and the want of ability to proceed further. Upload: 14-Aug-2017 12:19 SSMenber. Click Like and comment to support us! You're Read Essays of product Michel de Montaigne Part 124 online.
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